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Covalent DNA-Streptavidin Conjugates as Building Blocks for Novel Biometallic Nanostructures
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1998
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Supramolecular AssemblyEngineeringMolecular Self-assemblyMolecular BiologyDna NanotechnologyElectron MicroscopyOligonucleotide HybridizationBiophysicsSupramolecular AggregatesNanotechnologyNanobiotechnologyBioconjugationOligonucleotideMolecular EngineeringBiomolecular EngineeringNanomaterialsNatural SciencesSelf-assemblyCovalent Dna-streptavidin Conjugates
Supramolecular aggregates of DNA, RNA, streptavidin, immunoglobulin, and nanocrystalline metal clusters can be generated by self-assembly on the basis of oligonucleotide hybridization (shown schematically). Following selective immunosorption on surface-immobilized antigen, the biometallic hybrid is detectable by electron microscopy.