The Microvascular Response to Transdermal Iontophoresis of Insulin is Mediated by Nitric Oxide

Abstract

The main finding is that iontophoresis of insulin induces a dose-dependent vasodilation in the skin, which could be suppressed after pretreatment with a NO synthase inhibitor. This suggests that vasodilation in the skin after iontophoresis of insulin is mediated by the NO pathway.