Effects of Mirtazapine on the Sleep Wake Rhythm of Geriatric Patients with Major Depression: An Exploratory Study with Actigraphy

Abstract

Mirtazapine produces minimal changes on actigraphic measures in the sleep of elderly outpatients. Sleep produced by mirtazapine indicates a more pronounced effect in ≥ 80-year-old patients. This differential response should be considered during treatment of this clinical population.