Synthesis of pyrazolo[3,4-d]pyrimidines by intramolecular cycloaddition of azahexatrienes - Concepedia

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Synthesis of pyrazolo[3,4-d]pyrimidines by intramolecular cycloaddition of azahexatrienes

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1977

Year

Fumio Yoneda, Tomohisa Nagamatsu, Tetsuya Nagamura, K. SENGA

Journal of the Chemical Society Perkin Transactions 1

Aromatic AldehydesHeterocyclicMedicineAldehyde Pyrimidin-6-ylhydrazonesIntramolecular CycloadditionOrganic ChemistryStereoselective SynthesisHeterocycle ChemistryPharmacologyDerivative (Chemistry)Drug Discovery

Abstract

Treatment of aldehyde pyrimidin-6-ylhydrazones with aromatic aldehydes (or treatment of 6-hydrazinopyrimidines with aromatic aldehydes in excess) in dimethylformamide under reflux gave 2,3-disubstituted pyrazolo[3,4-d]pyrimidines.