Concepedia

Co-delivery of an antisense oligonucleotide and 5-fluorouracil using sustained release poly (lactide-co-glycolide) microsphere formulations for potential combination therapy in cancer

Majad Hussain, Gary Beale, Marcus Hughes, Saghir Akhtar

International Journal of Pharmaceutics · 2002 · 50 citations · 12 references

DOI

Concepts

References

12

Polyalkylcyanoacrylate Nanoparticles as Polymeric Carriers for Antisense Oligonucleotides

Christine Chavany, Trung Le Doan, Patrick Couvreur et al. · Pharmaceutical Research · 1992 · 149 citations

, , +16

Local and sustained delivery of 5-fluorouracil from biodegradable microspheres for the radiosensitization of glioblastoma

Philippe Meneï, Marie‐Claire Venier‐Julienne, E. Gamelin et al. · Cancer · 1999 · 130 citations

, , +10

The cellular delivery of antisense oligonucleotides and ribozymes

Marcus D. Hughes, Majad Hussain, Qamar Nawaz et al. · Drug Discovery Today · 2001 · 95 citations

, , +14

Antisense oligonucleotide delivery to cultured macrophages is improved by incorporation into sustained-release biodegradable polymer microspheres

Saghir Akhtar, Karen J. Lewis · International Journal of Pharmaceutics · 1997 · 61 citations

, , +12

Antitumor activity of a PKC-alpha antisense oligonucleotide in combination with standard chemotherapeutic agents against various human tumors transplanted into nude mice.

Thomas Geiger, Marcel A. Müller, Nickolas M. Dean et al. · PubMed · 1998 · 58 citations

, , +9