Publication | Closed Access
Effect of the Peptide PHI-27 on Prolactin Release in vitro
61
Citations
0
References
1983
Year
Peptide ScienceGastrointestinal Peptide HormonePituitary GlandPhi-like ImmunoreactivityNeuroendocrine MechanismHypothalamic PeptideProteomicsGlucagon-secretin GroupHealth SciencesHypothalamusPeptide BelongingNervous SystemEndocrinologyPharmacologyNeurophysiologyNeuroanatomyPhysiologyPeptide TherapeuticNeurosciencePeptide Phi-27Central Nervous SystemMedicineNeuropeptides
The present study demonstrates that PHI, a peptide belonging to the glucagon-secretin group and thus structurally similar to VIP, can release prolactin from dispersed rat anterior pituitary cells and also causes release of prolactin from hemipituitaries. PHI-like immunoreactivity has previously been demonstrated in a hypothalamic system with nerve endings in the median eminence, and, taken together, these findings suggest that PHI may represent a physiologic prolactin-releasing factor.