Dirhodium Tetra(N-arylsulfonylprolinates) as Chiral Catalysts For Asymmetric Transformations of Vinyl- and Aryldiazoacetates

Abstract

Rhodium(II( prolinates are superb catalysts for asymmetric transformations of vinyldiazoacetates and phenyldiazoacetates. The most well-developed transformation is the [3 + 4] annulation between vinyldiazoacetates and dienes which is a very general method for the stereoselective synthesis of highly functionalized seven-membered rings. Recent studies have led to a general method for asymmetric intermolecular C–H activation which displays promising regio- and diastereocontrol in addition to the enantiocontrol.