Experimental Biology and Medicine · 1956 · 39 citations · 0 references
Veterinary MedicineImmunologyInfectious DiseasesImmunizationVaccine ImmunologyVaccinologyAdult ImmunizationClinical Development Of VaccinesVaccinationVaccine DeliveryVaccine EffectivenessViral VaccinesAcute Respiratory Infection PreventionAdenoviral VectorsAdenovirus VaccinesAdenovirus VectorsControl Group DesignField Trial EvaluationMatched Control GroupVaccination Against Respiratory Infections
SummaryThe development, preparation and field evaluation of a highly effective formalin-killed vaccine against acute respiratory illnesses caused by viruses of the RI (Adenovirus) family has been described. The vaccine, prepared from infected tissue cultures of monkey renal epithelium, contained types 4 and 7 virus and was not injurious upon human injection. In human volunteers given a single 1 ml dose of vaccine intramuscularly, it induced high levels of neutralizing antibody. In 311 recruits, vaccinated at Fort Dix, N. J., it produced a marked reduction in the incidence of acute respiratory illness beginning one week after the initial dose of vaccine; only 4.8% of those receiving RI vaccine were hospitalized for respiratory illness compared with 23.8% of the control group of 313 which received placebo.