Structure inducing ionic liquids—enhancement of alpha helicity in the Abeta(1–40) peptide from Alzheimer's disease

Abstract

We have studied the impact of ionic liquid solvents on the structure of the Abeta(1-40) peptide from Alzheimer's disease and found that ionic liquid solvents were able to induce a conformational change in the structure of the Abeta(1-40) peptide. This conformational change impacts the self-assembly of the peptide into amyloid fibrils.