The Effect of a Combined Preparation of Trimethoprim and Sulphamethoxazole following Short-Term and Long-Term Administration on the Flora of the Human Gut

Concepts

Life SciencesMicrobiologyPharmacologyAntimicrobial PharmacotherapyBacteriologyMedical MicrobiologyAntibiotic ResistanceAntimicrobial PharmacodynamicsAntimicrobial TherapyGut MicrobiotaResistance In Gram-positive BacteriaAntibiotic Effects On The Gut MicrobiomeAntibiotic-associated Microbiota ChangesGut Microbiota EffectsIntestinal Microbiota ModulationResearch With Human SubjectsTrimethoprim-sulfamethoxazole Therapy

Abstract

The effect of the combination preparation TMP/SMZ on the alimentary flora of human subjects was investigated at different doses. Following the short-term administration of the preparation, E. coli was particularly markedly reduced at doses as low as one tablet a day. The other alimentary organisms, however, showed no pronounced changes. Enterobacteriaceae, particularly E. coli, were markedly reduced in the course of long-term treatment, with four tablets daily for 3 months. No resistant populations were found. The response of enterococci, anaerobic lactobacteria and Gram-negative bacteria of the Bacteroidaceae family showed no uniformity. No overgrowth of the alimentary flora by Pseudomonas, staphylococci or Candida was observed.