Direct Benzylic Alkylation via Ni-Catalyzed Selective Benzylic sp³ C−O Activation

Abstract

This article demonstrates the first cross coupling of benzyl ether with Grignard reagents via Ni-catalyzed benzylic sp3 C−O activation with high efficiency and excellent chemoselectivity. Benzylic sp3 C−O and aryl sp2 C−O were differentiated, controlled by ligands.