GLOMERULOTROPIC ACTIVITY OF AN ACETONE EXTRACT OF PINEAL TISSUE¹

Abstract

A crude acetone-soluble fraction of beef pineal tissue was assayed for steroidogenic activity in the decerebrate dog. Aldosterone secretion was markedly stimulated without a significant effect on cortisol output. When the material was partitioned between water and hexane, the hexane fraction was found to contain the activity. The finding is taken as additional evidence for the existence of glomerulotropin, a specific hormone for aldosterone secretion, in pineal tissue or an adjacent structure.