Interleukin‐6 and type I interferon–regulated genes and chemokines mark disease activity in dermatomyositis

Abstract

These results suggest that serum IL-6 production and the type I IFN gene signature are candidate biomarkers for disease activity in adult and juvenile DM. Coregulation of the expression of IFN-driven chemokines and IL-6 suggests a novel pathogenic linkage in DM.