Methods of Analysis of Antiepileptic Drugs

Abstract

This book contains the proceedings of the Workshop on the Determination of Anti-epileptic Drugs in Body Fluids, held in Noordwijkerhout, the Netherlands, in April 1972. The drugs for which assaying methods are described include the conventional agents diphenylhydantoin, phenobarbital, primidone, and ethosuximide, as well as carbamazepine, sultiame, benzodiazepines, pheneturide, and dipropylacetate. The analytical techniques talked about include spectrophotometry, fluorometry, thin-layer chromatography, high-pressure liquid chromatography; and gas-liquid chromatography, to which most of the space and attention is devoted. Technical specifications for methods used in 19 laboratories are given in the form of tables at the end of the book. Some presentations are brief comments or summaries about the techniques used or the results obtained in the author's laboratory or both, referring for details to previous publications. Others contain fair amounts of technical details; but except in a few, sufficiently complete detailed descriptions to allow a laboratory to duplicate a specific method