The Analgesic Effect of Xenon on the Formalin Test in Rats: A Comparison with Nitrous Oxide

Abstract

Inhaled xenon suppressed nociceptive behaviors, c-fos expression, and activation of the N-methyl-D-aspartate receptor during the formalin test in rats. Xenon's analgesic effect was speculated to result from the inhibition of the N-methyl-D-aspartate receptor in vivo.