Dmdp - a Plant-Derived Sugar Analogue With Systemic Activity Against Plant Parasitic Nematodes

Abstract

The naturally occurring sugar analogue DMDP (2,5-Dihydroxymethyl-3, 4-dihydroxypyrrolidine) also known as (2R, 3R, 4R, 5R) -2,5-bis (hydroxymethyl)pyrrolidine-3, 4-diol), has been isolated from tropical legumes in the genera Lonchocarpus and Derris, and found to have a range of activities against several plant parasitic nematode species. In vitro studies demonstrated that DMDP at 25 μg ml-1 inhibited cyst hatch of Globodera pallida by 41%, and at 1000 μM ml-1 immobilised 53% of G. rostochiensis juveniles after 72 h exposure. DMDP applied as a foliar spray showed systemic activity and decreased root galling of tomato by Meloidogyne spp. It was also effective when applied as a soil drench or seed dressing. The compound applied as a 30 μg ml-1 soil drench also inhibited virus acquisition and transmission, and root galling by Xiphinema diversicaudatum on Petunia. At 100 μg ml-1 DMDP enhanced the control of Globodera spp. on the partially resistant potato cv. Heather, reducing both the number of cysts/root and eggs/g soil. The potential of this systemic, phloem-mobile plant compound in the integrated control of nematodes is discussed.