Adipophilin Enhances Lipid Accumulation and Prevents Lipid Efflux From THP-1 Macrophages

Abstract

Our results showed that stimulation of adipophilin expression in macrophages by modified LDL promotes triglycerides and cholesterol storage and reduces cholesterol efflux. Therefore, adipophilin might contribute, in vivo, to lipid accumulation in the intima of the arterial wall.