Isocoumarin Glucosides from the Scale Insect Fungus <i>Torrubiella tenuis</i> BCC 12732

Abstract

Three new isocoumarin glucosides (1, 3, and 4), 6,8-dihydroxy-3-methylisocoumarin (2), and 6,8-dihydroxy-3-hydroxymethylisocoumarin (5) were isolated from the scale insect pathogenic fungus Torrubiella tenuis BCC 12732. Structures of these compounds were elucidated using NMR spectroscopic and MS spectrometric analyses. Compound 5 exhibited moderate anti-HSV-1 and antimycobacterial activities with IC(50) and MIC values of 50 and 25 microg/mL, respectively.