Enantioselective Inclusion Complexation ofN-Nitrosopiperidines by Steroidal Bile Acids

Abstract

N-nitrosamines, whose chirality is solely due to hindered rotation about the N-N bond, are enantioselectively enclathrated by the crystal host matrices of cholic or deoxycholic acid, as evidenced by X-ray crystallography (see structure in picture) and CD spectra.