ORIGIN OF ADENOCARCINOMA IN BARRETT’S ESOPHAGUS: P53 AND KI67 EXPRESSION AND HISTOPATHOLOGIC BACKGROUND

Abstract

Adenocarcinoma develops from mixed columnar epithelium, either intestinal or gastric, showing both the gastric and the intestinal patterns; thus, tumors can also grow in columnar epithelium without intestinal metaplasia. Barrett's esophagus should be followed up for the possibility of progression to malignancy, especially when the segment is longer than 3 cm.