Ultrasound assessment of short‐term ocular vascular effects of intravitreal injection of bevacizumab (Avastin^®) in neovascular age‐related macular degeneration

Abstract

Intravitreal bevacizumab acutely improved VA and reduced central macular thickness in wet AMD. Ultrasound imaging revealed that BFVs decreased in all retrobulbar arteries, suggesting that after local diffusion, bevacizumab exerts a short-term regional effect. Bevacizumab might therefore induce hypoperfusion of the whole eye, which may correspond to a vascular side-effect.