Serotonin increases protective duodenal bicarbonate secretion via enteric ganglia and a 5-HT₄-dependent pathway

Abstract

Stimulation of the duodenal protective secretion by 5-HT thus involves receptors of the 5-HT4 subtype as well as nicotinic transmission, the myenteric plexus being a likely location. In addition, serotonin acts on enterocyte membrane receptors, inducing intracellular calcium signalling.