PDMS (Polydimethylsiloxane) Microfluidic Chip Molding for Love Wave Biosensor

Abstract

We present the development of new Polydimethylsiloxane (PDMS) chips, which are coupled with Love acoustic wave sensors to realize a detection cell of bio-organisms in liquid media. Three generations of biocompatible PDMS chips have been developed. Built-in thermistors allow a thermal control ({plus minus}0.05{degree sign}C). Unlike the usual assemblies, this chip is maintained by pressure on the sensor and not bonded welded on its surface. This technique makes it entirely removable and cleanable. Therefore, the surface of the sensor can be functionalised or regenerated. The realization of these chips is quick and inexpensive.