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Comparative Effects of Cyclosporine A and FK-506 on Endothelin Secretion by a Cultured Renal Cell Line, LLC-PK1
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1991
Year
Renal PathologyPharmacotherapyPutative EndothelinCellular PhysiologyInflammationMolecular PharmacologyRenal FunctionRenal PharmacologyCell SignalingSpecific Receptor AntagonistsMolecular PhysiologyVascular PharmacologyVascular BiologyComparative EffectsRenal PathophysiologyPharmacologyCell BiologySignal TransductionEndothelin SecretionPhysiologyEndothelial DysfunctionCyclosporine AMedicineNephrologyKidney Research
Cyclosporine A (CSA) stimulated endothelin secretion by a cultured renal epithelial cell line, LLC-PK1. A less nephrotoxic immunosuppressant (FK-506) did not affect endothelin secretion. Putative endothelin converting enzyme inhibitors or specific receptor antagonists may therefore prevent CSA nephrotoxicity.