Insulin-Like Growth Factor-1 as a Predictive Biomarker for Metastatic Uveal Melanoma in Humans

Abstract

IGF-1 levels in 10-years' disease-free UM patients were significantly lower than those in healthy subjects and were even lower in metastatic patients. IGF-1 levels decreased toward the diagnosis of metastases. Therefore, serum IGF-1 level may be used as a predictive biomarker for metastatic UM when measured repeatedly.