EFFECTS OF ANOXIA ON FORCE, INTRACELLULAR CALCIUM AND LACTATE PRODUCTION OF URINARY BLADDER SMOOTH MUSCLE FROM CONTROL AND DIABETIC RATS

Abstract

The results reveal that urinary bladder smooth muscle from diabetic rats has a reduced ability to maintain contraction under anoxic conditions. This most likely reflects a greater energy limitation as evidenced by the reduced J(Lac) in diabetic muscles. In both diabetic and control muscles there was a marked dissociation between force and [Ca2+]i when oxidative metabolism was inhibited. This may indicate preferential use of glycolytically produced ATP for maintenance of [Ca2+]i homeostasis under these conditions.