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Effect of Δ<sup>9</sup>- and Δ<sup>8</sup>-Tetrahydrocannabinol on the Peripheral Autonomic Nervous System <i>In Vitro</i>
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1973
Year
NeurotransmitterPharmacotherapyNeurotransmissionExperimental PharmacologyIsolated MusclesCannabinoid PharmacologyMolecular PharmacologyIleum PreparationsTransient PotentiationNeurochemistryAnesthetic PharmacologyHealth SciencesCannabis UseBehavioural PharmacologyBehavioral PharmacologyNeuropharmacologyNervous SystemNeuromuscular PhysiologyPharmacologyNeurophysiologyPhysiologyNeuroscienceCentral Nervous SystemMedicine
The purpose of this study was to evaluate the effect of Δ 9 - and Δ 8 tetrahydrocannabinol (THC) on some isolated muscles. The results observed show that Δ 9 - and Δ 8 THC do not have agonistic activity on the vas deferens, the phrenic nerve – diaphragm, and the ileum preparations. On the other hand, both compounds produce a transient potentiation followed by the inhibition of the acetylcholine-induced contraction as well as a potentiation of the musculotropic activity of noradrenaline on the isolated vas deferens. Furthermore, we have observed that Δ 8 THC reverses the anti-cholinergic action of atropine, conteracts the anti-angiotensin activity of morphine, and finally, abolishes the potentiation of noradrenaline produced by cocaine. On the phrenic nerve – diaphragm preparation Δ 9 THC does not modify the contraction produced by nerve stimulation but alters the effect of physostigmine, an anti-cholinesterase inhibitor.