miR-34a Induces the Downregulation of Both <i>E2F1</i> and <i>B-Myb</i> Oncogenes in Leukemic Cells

Abstract

Owing to the role of B-Myb and E2F1 transcription factors in controlling cell-cycle progression of leukemic cells, the downregulation of these oncogenes by miR-34a suggests the usefulness of therapeutic approaches aimed to modulate the levels of miR-34a.