Improved Myocardial β-Adrenergic Responsiveness and Signaling With Exercise Training in Hypertension

Abstract

Exercise training in hypertension improves the inotropic and lusitropic responsiveness to beta-adrenergic receptor stimulation despite augmenting LV wall thickness. A lower GRK2 abundance and an increased phosphorylation of key Ca2+ cycling proteins may be responsible for the above putative effects.