Effect of Carvedilol on Diastolic Function in Patients with Diastolic Heart Failure and Preserved Systolic Function. Results of the Swedish Doppler-Echocardiographic Study (SWEDIC)

Abstract

Treatment with carvedilol resulted in a significant improvement in E:A ratio in patients with heart failure due to a LV relaxation abnormality. E:A ratio was found to be the most useful variable to identify diastolic dysfunction in this patient population. This effect was observed particularly in patients with higher heart rates at baseline.