A soluble form of the macrophage-related mannose receptor (MR/CD206) is present in human serum and elevated in critical illness

Abstract

This study documents, for the first time, the presence of sMR in human serum and describes an optimised ELISA suitable for quantitative measurements. Levels of sMR are strongly elevated in several disease states, including sepsis and liver disease, and the protein therefore shows promise as a new biomarker.