PharmacyPhysiologyToxicologyMechanisms Of ToxicityMetabolismPoisoning ManagementCarbon MonoxideCarbon Monoxide PoisoningCarbon Monoxide ToxicologyHemoglobin PhysiologyHypoxia PhysiologyOxygen TransportCarbon Monoxide IntoxicationCarbon Monoxide Poisoning PathophysiologyCarbon Monoxide Transport
ACUTE carbon monoxide poisoning accounts for approximately 3,500 accidental or suicidal deaths per year in the United States. Many are preventable by medical management based on physiologic understanding. <h3>Pathophysiology</h3> Carbon monoxide poisoning and its mechanism have been known since Claude Bernard reported in 1857 that this gas caused death by hypoxia, consequent on its reversible combination with hemoglobin.<sup>1</sup>The equilibrium reactions were well described by Haldane in 1895.<sup>2</sup>Excellent reviews are available.<sup>3,4</sup> The effects of CO in concentrations encountered clinically are based entirely on its combination with hemoglobin, displacement of oxygen, and consequent disruption of the O<sub>2</sub>transport system. Carbon monoxide competes with O<sub>2</sub>for binding sites on the hemoglobin molecule, and carboxyhemoglobin (COHb) is without practical function as a carrier of O<sub>2</sub>. Because affinity of CO for hemoglobin is 230 to 270 times as great as that of O<sub>2</sub>, the latter is
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Applied Respiratory Physiology
J. F. Nunn, Stephen A. Vitkun · Anesthesiology · 1994 · 732 citations · Full text
Morbidity from Acute Carbon Monoxide Poisoning at Three-year Follow-up
J. Stanley Smith, S. Brandon · BMJ · 1973 · 241 citations · Full text
Pharmacy, Psychiatry, Toxicology +16
The Relation of the Action of Carbonic Oxide to Oxygen Tension
J. S. Haldane · The Journal of Physiology · 1895 · 161 citations
Life Sciences, Chemistry, Physiology +10
Carbon Monoxide as a Tissue Poison
J. B. S. Haldane · Biochemical Journal · 1927 · 146 citations · Full text