Phosphorylated TDP‐43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Abstract

These results suggest that phosphorylated TDP-43 is a major component of the inclusions, and that abnormal phosphorylation of TDP-43 is a critical step in the pathogenesis of FTLD-U and ALS. Phosphorylation-specific antibodies will be powerful tools for the investigation of these disorders.