Stachybocins, Novel Endothelin Receptor Antagonists, Produced by Stachybotrys sp. M6222. II. Structure Determination of Stachybocins A, B and C.

Abstract

The structures of stachybocins A, B and C, new endothelin receptor antagonist, were determined by NMR spectral analysis using pulse-field-gradient technique. Stachybocin A consists of two spirobenzofuran units each fused to a substituted decalin, which were connected by a lysine residue. Stachybocins B and C are derivatives of stachybocin A with an additional hydroxy group at the same position in the different decalin unit.