Concepedia

Therapeutic Effects of Bacteriophage Cpl-1 Lysin against <i>Streptococcus pneumoniae</i> Endocarditis in Rats

José M. Entenza, Jutta M. Loeffler, Denis Grandgirard, Vincent A. Fischetti, Philippe Moreillon

Antimicrobial Agents and Chemotherapy · 2005 · 145 citations · 10 references

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Abstract

Cpl-1, a pneumococcal phage lytic enzyme, was tested in rats with experimental endocarditis due to Streptococcus pneumoniae WB4. High-dose regimen Cpl-1 eliminated pneumococci from blood within 30 min and decreased bacterial titers in vegetations (>4 log10 CFU/g) within 2 h. Rapid bacterial lysis induced by Cpl-1 treatment increased cytokine secretion noticeably.

References

10

Phage Lytic Enzyme Cpl-1 as a Novel Antimicrobial for Pneumococcal Bacteremia

Jutta M. Loeffler, Svetolik Djurkovic, Vincent A. Fischetti · Infection and Immunity · 2003 · 270 citations · Full text

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Phage lytic enzymes as therapy for antibiotic-resistant Streptococcus pneumoniae infection in a murine sepsis model

Isabel Jado · Journal of Antimicrobial Chemotherapy · 2003 · 217 citations

, , +13

Synergistic Lethal Effect of a Combination of Phage Lytic Enzymes with Different Activities on Penicillin-Sensitive and -Resistant <i>Streptococcus pneumoniae</i> Strains

Jutta M. Loeffler, Vincent A. Fischetti · Antimicrobial Agents and Chemotherapy · 2002 · 146 citations · Full text

, , +16

Natural history of aortic valve endocarditis in rats

E Héraïef, M. P. Glauser, Lawrence R. Freedman · Infection and Immunity · 1982 · 129 citations · Full text

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Synergistic Killing of <i>Streptococcus pneumoniae</i> with the Bacteriophage Lytic Enzyme Cpl-1 and Penicillin or Gentamicin Depends on the Level of Penicillin Resistance

Svetolik Djurkovic, Jutta M. Loeffler, Vincent A. Fischetti · Antimicrobial Agents and Chemotherapy · 2005 · 108 citations · Full text

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