Exceptionally high <i>in vitro</i> antitumor activity of substituted triphenyltin benzoates including salicylates against a human mammary tumor, MCF‐7, and a colon carcinoma, WiDr

Abstract

Abstract Nine new substituted triphenyltin benzoates of the type Ar 3 SnOOCC 6 H 2 XYZ [X = Y = H, Z = 2‐OCH 3 and 4‐F; X = H, Y = 3‐F, Z = 5‐F; X = H, Y = 2‐OH, Z = 5‐Cl, 5‐NH 2 , 5‐OCH 3 and 5‐SO 3 H; X = 2‐OH, Y = 3‐CH(CH 3 ) 2 and Z = 5‐CH(CH 3 ) 2 ] were prepared and possess considerable in vitro antitumor activity against two human tumor cell lines (MCF‐7, a mammary tumor, and WiDr, a colon carcinoma) comparable with that of mitomycin C.