Total Synthesis of 7,11-Cyclobotryococca-5,12,26-triene Using an Oxidative Radical Cyclization as a Key Step

Abstract

An efficient total synthesis of the novel botryococcene-related hydrocarbon 7,11-cyclobotryococca-5,12,26-triene is reported that uses, as a key step, an oxidative radical cyclization of a 4-pentenyl malonate for the synthesis of a [3.3.0]-bicyclic gamma-lactone.