The synthesis of pyrimidin-4-yl substituted α-amino acids. A versatile approach from alkynyl ketones

Abstract

The reaction of amidines with α-amino acid alkynyl ketones is shown to be a versatile route to pyrimidin-4-yl substituted α-amino acids. This route is also applicable to a parallel synthesis approach and has allowed the formation of a range of pyrimidin-4-yl substituted α-amino acids, including the naturally occurring α-amino acid L-lathyrine 4.