Multi-membrane hydrogel fabricated by facile dynamic self-assembly

Abstract

Multi-membrane hydrogels are newly promising carriers in biomedical fields. We fabricate alginate-based onion-like multi-membrane hydrogels starting from a template gel-core to shells through a dynamic self-assembly method, and investigate the influence of various factors on the formation of the complex system in detail. By precisely controlling the process of preparation, multi-layered hydrogels of different shapes either with or without defined internal space between separated layers can be prepared. And a pulse-like delivery of macromolecule has been achieved by this architecture.