The Use of Differential Chemical Shifts for Determining the Binding Site Location and Orientation of Protein-Bound Ligands

Abstract

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTThe Use of Differential Chemical Shifts for Determining the Binding Site Location and Orientation of Protein-Bound LigandsAles Medek, Philip J. Hajduk, Jamey Mack, and Stephen W. FesikView Author Information Pharmaceutical Discovery Division Abbott Laboratories, Abbott Park, Illinois 60064 Cite this: J. Am. Chem. Soc. 2000, 122, 6, 1241–1242Publication Date (Web):January 29, 2000Publication History Received5 November 1999Revised14 December 1999Published online29 January 2000Published inissue 1 February 2000https://pubs.acs.org/doi/10.1021/ja993921mhttps://doi.org/10.1021/ja993921mrapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views1225Altmetric-Citations82LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Genetics,Ligands,Peptides and proteins,Protein structure,Screening assays Get e-Alerts