Science · 1973 · 32 citations · 10 references
Life SciencesBiochemistryEndocrinologyHormone BiochemistryNeuroendocrinologySteroid BiochemistryAdrenal Axis RegulationAdrenal EndocrinologyAdrenal HormonesAdrenal Steroid HormonesAdrenal SteroidogenesisSteroidogenesis RegulationAdrenal Cortex FunctionAdrenal Cortex PhysiologyAdrenal Cortical HormonesAdrenal Steroid MetabolismAdrenal Steroidogenesis RegulationAdrenocortical SecretionAdrenocorticotropic Hormone RegulationSteroidogenic Regulation
Cells from the adrenals of hypophysectomized rats (up to 28 days after operation) require less adrenocorticotropic hormone to induce one-half maximal rate of production of 3',5'-adenosine monophosphate than do cells from the adrenals of intact rats. A corresponding increase in sensitivity is reflected in the steroidogenic response to adrenocorticotropic hormone up to 2 days after hypophysectomy.
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