Angewandte Chemie International Edition in English · 1984 · 35 citations · 6 references
Position 9BiosynthesisBioorganic ChemistryBiochemistryHigh Cytostatic ActivityStereoselective Total SynthesisChiral CenterNatural SciencesMolecular BiologyPeptide SynthesisStereoselective SynthesisChemical BiologyNatural Product SynthesisSynthetic ChemistryEnantioselective Synthesis
The tetrapeptide chlamydocin 1 exhibits extremely high cytostatic activity in vitro. In the stereoselective synthesis of 1, the chiral center at position 9 was obtained from natural tartaric acid, that at the α-position by enantioselective hydrogenation from the dehydroamino acid.
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