A Study of Moderately Differentiated Neuroendocrine Carcinomas of the Larynx and an Examination of Non‐Neoplastic Larynx Tissue for Neuroendocrine Cells

Abstract

Moderately differentiated or large-cell NEC is a more favored term than atypical carcinoid until more refined classifications for upper respiratory tract NEC are agreed on. Despite the confirmed presence of neuroendocrine cells in the respiratory epithelium of the larynx, the origin of laryngeal NEC remains unknown. p53 mutation might be one of the major molecular steps in the pathogenesis of laryngeal NEC.