Publication | Closed Access
Synthesis of 1‐hydroxyxanthines
18
Citations
8
References
1964
Year
Enantioselective SynthesisEngineeringBiochemistryNatural SciencesDiversity-oriented SynthesisModified Lossen RearrangementOrganic ChemistryStereoselective SynthesisChemistrySynthesis MethodNatural Product SynthesisCorresponding N‐alkyl‐substituted GlycinesSynthetic ChemistryDiethyl 1‐Alkyl‐4,5‐imidazoledicarboxylatesBiomolecular Engineering
Abstract The synthesis of 1‐hydroxy‐7‐alkylxanthines from the corresponding diethyl 1‐alkyl‐4,5‐imidazoledicarboxylates by means of a modified Lossen rearrangement is described. The products were characterized by their spectra and identified by hydrolysis with concentrated hydrochloric acid at elevated temperatures to the corresponding N‐alkyl‐substituted glycines.
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