Helvetica Chimica Acta · 1957 · 18 citations · 2 references
Laevo‐rotatory IsomerButyl Side ChainBioorganic ChemistryOrganic ChemistryChemistryHeterocycle ChemistryChemical DerivativePharmaceutical ChemistryDer 4‐StändigenDerivativesBiochemistryHydroxy GroupNatural Product SynthesisPharmacologyNatural SciencesMedicineDerivative (Chemistry)Synthetic ChemistryDrug Analysis
Abstract The synthesis of three derivatives of phenylbutazone with a hydroxy group in the butyl side chain is described, among them γ‐hydroxy‐phenylbutazone [1, 2‐diphenyl‐4‐(γ‐hydroxy‐n‐butyl)‐pyrazolidine‐3,5‐dione] (IV), the laevo‐rotatory isomer of which is one of the metabolites of phenylbutazone in man.
2