H DNA amplification in Leishmania resistant to both arsenite and methotrexate

The multidrug transporter, a double-edged sword.

Michael M. Gottesman, I Pastan · Journal of Biological Chemistry · 1988 · 766 citations · Full text

Life Sciences, Pharmacology, Intracellular Transport +10

Induction of Gene Amplification by Arsenic

Te‐Chang Lee, Noriho Tanaka, Patricia W. Lamb et al. · Science · 1988 · 213 citations

Medicine, Genetics, Toxicology +17

The H circles of Leishmania tarentolae are a unique amplifiable system of oligomeric DNAs associated with drug resistance.

Theodore C. White, F. Fase-Fowler, Henri G.A.M. van Luenen et al. · Journal of Biological Chemistry · 1988 · 125 citations · Full text

Life Sciences, Genetics, Molecular Biology +13

Stable Amplified DNA in Drug-Resistant <i>Leishmania</i> Exists as Extrachromosomal Circles

Edward P. Garvey, Daniel V. Santi · Science · 1986 · 121 citations

Life Sciences, Genetics, Molecular Biology +13

Reductions in methotrexate and folate influx in methotrexate-resistant lines of Leishmania major are independent of R or H region amplification.

Thomas E. Ellenberger, Stephen M. Beverley · Journal of Biological Chemistry · 1987 · 74 citations · Full text

Life Sciences, Genetics, Molecular Biology +16