New Oxazole‐Based Conformationally Restricted Peptidomimetics: Design and Synthesis of Pseudopeptides

Abstract

A general synthesis of a new class of optically active amino acids containing an oxazole moiety is described along with a strategy for their insertion into a peptidomimetic chain. A modified portion of endothelin-1 is prepared as a potential receptor antagonist. The procedure presented is based on readily available materials and can be performed in multigram quantities.