Stimulation of Bradykinin B₁Receptors Induces Vasodilation in Conductance and Resistance Coronary Vessels in Conscious Dogs

Abstract

In the conscious dog, B(1) receptors are present in coronary vessels, and their stimulation produces vasodilation in conductance and resistance vessels, which is mediated essentially by NO but not modulated by angiotensin-converting enzyme. However, the coronary vasodilation induced by B(1) receptor stimulation is not as great as that produced by B(2) receptor stimulation.