Longitudinal Follow-up of Cardiac Structure and Functional Changes in an Infarct Mouse Model Using Retrospectively Gated Micro-Computed Tomography

Abstract

We have demonstrated the first use of dynamic micro-CT for monitoring cardiac remodeling, resulting from myocardial infarction, over time. The fast scan times (<1 minute) and ability to track individual animals over an entire study make this quantitative noninvasive technique a promising tool for in vivo studies of cardiac disease in mouse models.