Copper Complex of Aminoisoborneol Schiff Base Cu₂(SBAIB‐d)₂: An Efficient Catalyst for Direct Catalytic Asymmetric Nitroaldol (Henry) Reaction

Abstract

Abstract A new bifunctional copper complex of the aminoisoborneol Schiff base – Cu 2 (SBAIB‐d) 2 – has been developed for the effective direct catalytic asymmetric Henry reaction. One mol% of this catalyst produces the expected Henry products in high yields (up to 99%) with excellent enantioselectivities (up to 98% ee ). The utility of the present catalyst was also extended to the Henry reaction with nitroethane and 1‐nitropropane that furnished the corresponding products in moderate to high yields (up to 99%) with moderate to high enantioselectivities of syn (up to 98% ee ) and anti (up to 98% ee ) diastereomers. The highlights of this catalytic system are easy manipulation, air and moisture tolerance, the need for 1 mol% of an easily synthesizable catalyst and the high enantioselectivities achieved for a wide range of substrates.